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What is Robaxin and how is it used?

Robaxin is a prescription medicine used to treat the symptoms of muscle spasms caused by pain or injury and Tetanus. Robaxin may be used alone or with other medications.

- Robaxin belongs to a class of drugs called Skeletal Muscle Relaxants.
- It is not known if Robaxin is safe and effective in children younger than 16 years of age.

robaxin®/robaxin®- 750 (methocarbamol tablets, USP), a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.

The chemical name of methocarbamol is 3-(2-methoxyphenoxy) -1,2propanediol 1-carbamate and has the empirical formula C₁₁H₁₅NO₅. Its molecular weight is 241.24. The structural formula is shown below.

he chemical name of methocarbamol is 3-(2-methoxyphenoxy) -1,2propanediol 1-carbamate and has the empirical formula C11H15NO5. Its molecular weight is 241.24.

Methocarbamol is a white powder, sparingly soluble in water and chloroform, soluble in alcohol (only with heating) and propylene glycol, and insoluble in benzene and n-hexane.

robaxin® is available as a light orange, round, filmcoated tablet containing 500 mg of methocarbamol, USP for oral administration. The inactive ingredients present are corn starch, FD&C Yellow 6, hydroxypropyl cellulose, hypromellose, magnesium stearate, polysorbate 20, povidone, propylene glycol, saccharin sodium, sodium lauryl sulfate, sodium starch glycolate, stearic acid, titanium dioxide.

robaxin®- 750 is available as an orange capsuleshaped, filmcoated tablet containing 750 mg of methocarbamol, USP for oral administration. In addition to the inactive ingredients present in robaxin®, robaxin® 750 also contains D&C Yellow 10.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with risperidone may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

This medicine may cause some people to become dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests. .

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines) and herbal or vitamin supplements.

Before Using Robaxin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of methocarbamol in children below 16 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methocarbamol in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- - Alfentanil
  - Alprazolam
  - Amobarbital
  - Aprobarbital
  - Benzhydrocodone
  - Bromazepam
  - Buprenorphine
  - Butabarbital
  - Butalbital
  - Butorphanol
  - Calcium Oxybate
  - Cannabidiol
  - Carisoprodol
  - Cetirizine
  - Chloral Hydrate
  - Chlordiazepoxide
  - Chlorzoxazone
  - Clobazam
  - Clonazepam
  - Clorazepate
  - Codeine
  - Dantrolene
  - Daridorexant
  - Diazepam
  - Dihydrocodeine
  - Doxylamine
  - Esketamine
  - Estazolam
  - Ethchlorvynol
  - Fentanyl
  - Flibanserin
  - Flunitrazepam
  - Flurazepam
  - Gabapentin
  - Gabapentin Enacarbil
  - Halazepam
  - Hydrocodone
  - Hydromorphone
  - Ketamine
  - Ketazolam
  - Lemborexant
  - Levocetirizine
  - Levorphanol
  - Lofexidine
  - Lorazepam
  - Lormetazepam
  - Loxapine
  - Magnesium Oxybate
  - Medazepam
  - Meperidine
  - Mephenesin
  - Mephobarbital
  - Meprobamate
  - Metaxalone
  - Methadone
  - Methohexital
  - Metoclopramide
  - Midazolam
  - Morphine
  - Morphine Sulfate Liposome
  - Nalbuphine
  - Nitrazepam
  - Oxazepam
  - Oxycodone
  - Oxymorphone
  - Pentazocine
  - Pentobarbital
  - Periciazine
  - Phenobarbital
  - Potassium Oxybate
  - Prazepam
  - Pregabalin
  - Primidone
  - Quazepam
  - Remifentanil
  - Remimazolam
  - Ropeginterferon Alfa-2b-njft
  - Scopolamine
  - Secobarbital
  - Sodium Oxybate
  - Sufentanil
  - Tapentadol
  - Temazepam
  - Thiopental
  - Tramadol
  - Trazodone
  - Triazolam
  - Zolpidem

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

How should I use Robaxin?

Take Robaxin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. This medicine is only part of a complete treatment program that may also include rest, physical therapy, or other pain relief measures.

Robaxin oral is taken by mouth. You may need to reduce your dose after the first 2 or 3 days of treatment. Carefully follow your doctor’s dosing instructions.

Robaxin injection is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection.

The injection is usually given as a single dose before you start taking the oral form.

Methocarbamol DOSAGE AND ADMINISTRATION

For Intravenous and Intramuscular Use Only. Total adult dosage should not exceed 30 mL (3 vials) a day for more than 3 consecutive days except in the treatment of tetanus. If the condition persists, a like course may be repeated after a drug-free interval of 48 hours. Dosage and frequency of injection should be based on the severity of the condition being treated and therapeutic response noted.

For the relief of symptoms of moderate degree, one dose of 1 gram (one 10 mL vial) may be adequate. Ordinarily this injection need not be repeated, as the administration of the oral form will usually sustain the relief initiated by the injection. For the severest cases or in postoperative conditions in which oral administration is not feasible, additional doses of 1 gram may be repeated every 8 hours up to a maximum of 3 g/day for no more than 3 consecutive days.

Directions For Intravenous Use

ROBAXIN Injectable may be administered undiluted directly into the vein at a maximum rate of three mL per minute. It may also be added to an intravenous drip of Sodium Chloride Injection (Sterile Isotonic Sodium Chloride Solution for Parenteral Use) or five percent Dextrose Injection (Sterile 5 percent Dextrose Solution); one vial given as a single dose should not be diluted to more than 250 mL for I.V. infusion. AFTER MIXING WITH I.V. INFUSION FLUIDS, DO NOT REFRIGERATE. Care should be exercised to avoid vascular extravasation of this hypertonic solution, which may result in thrombophlebitis. It is preferable that the patient be in a recumbent position during and for at least 10 to 15 minutes following the injection.

Directions For Intramuscular Use

When the intramuscular route is indicated, not more than five mL (one-half vial) should be injected into each gluteal region. The injections may be repeated at eight hour intervals, if necessary. When satisfactory relief of symptoms is achieved, it can usually be maintained with tablets.

Not Recommended for Subcutaneous Administration.

Special Directions For Use In Tetanus

There is clinical evidence which suggests that methocarbamol may have a beneficial effect in the control of the neuromuscular manifestations of tetanus. It does not, however, replace the usual procedure of debridement, tetanus antitoxin, penicillin, tracheotomy, attention to fluid balance, and supportive care. ROBAXIN Injectable should be added to the regimen as soon as possible.

For Adults

Inject one or two vials directly into the tubing of the previously inserted indwelling needle. An additional 10 mL or 20 mL may be added to the infusion bottle so that a total of up to 30 mL (three vials) is given as the initial dose (see PRECAUTIONS). This procedure should be repeated every six hours until conditions allow for the insertion of a nasogastric tube. Crushed methocarbamol tablets suspended in water or saline may then be given through this tube. Total daily oral doses up to 24 grams may be required as judged by patient response.

For Pediatric Patients

A minimum initial dose of 15 mg/kg or 500 mg/m² is recommended. This dosage may be repeated every six hours, if required. The total dose should not exceed 1.8 g/m² for 3 consecutive days. The maintenance dosage may be given by injection into tubing or by I.V. infusion with an appropriate quantity of fluid. See directions for I.V. use.

Robaxin side effects

Get emergency medical help if you have signs of an allergic reaction to Robaxin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Robaxin and call your doctor at once if you have:

- - - a light-headed feeling, like you might pass out;
    - slow heartbeats;
    - a seizure;
    - jaundice (yellowing of your skin or eyes); or
    - pain, bruising, swelling, or skin changes where the injection was given.

Common Robaxin side effects may include:

- - headache, dizziness, drowsiness;
  - fever;
  - confusion, problems with memory;
  - nausea, vomiting, upset stomach;
  - blurred vision, double vision;
  - flushing (warmth, redness, or tingly feeling);
  - sleep problems (insomnia); or
  - lack of coordination.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, extreme drowsiness, fainting, seizure, or coma.

What to avoid

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Drinking alcohol with this medicine can cause side effects.